K(+) depletion and the progression of hypertensive disease or heart failure. The pathogenic role of diuretic-induced aldosterone secretion.
نویسندگان
چکیده
After the introduction of chlorothiazide in 1958,1 as the first of many sulfonamide thiazide diuretics, these orally active diuretics rapidly became the cornerstone for treatment of patients with congestive heart failure (CHF) and other edematous states. These diuretics were also widely adopted for primary or adjuvant antihypertensive drug therapy. Since the beginning, it was recognized that such natriuretic-diuretic therapy in both of these disorders is regularly accompanied by demonstrable body potassium and magnesium deficiencies, often reflected by significant, albeit generally mild, observed decrements in plasma K and Mg levels. But because no particular problems were recognized with broad use of these diuretics, over the years physicians became increasingly sanguine about their occurrence. Accordingly, thiazide diuretics and then, beginning in 1966, the similar but more powerful loop diuretics (eg, furosemide) also became broadly used as primary or adjuvant treatments for high blood pressure and for the edematous state of CHF, cirrhosis with ascites, and nephrotic syndrome.
منابع مشابه
The Pathogenic Role of Diuretic-Induced Aldosterone Secretion
After the introduction of chlorothiazide in 1958,1 as the first of many sulfonamide thiazide diuretics, these orally active diuretics rapidly became the cornerstone for treatment of patients with congestive heart failure (CHF) and other edematous states. These diuretics were also widely adopted for primary or adjuvant antihypertensive drug therapy. Since the beginning, it was recognized that su...
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Aldosterone is an adrenal hormone that regulates sodium, fluid, and potassium balance. Jerome Conn first described the syndrome of autonomous and excessive aldosterone secretion or "primary aldosteronism." Contrary to the historical belief, recent studies indicate that primary aldosteronism is a common cause of hypertension with a prevalence of 5-10% among general hypertensive patients. Various...
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Heart failure due to a decline in cardiac performance initiates compensatory neurohormonal mechanisms in an effort to maintain systemic perfusion. Ongoing neurohormonal activation may have deleterious consequences for cardiac performance, ventricular remodeling, myocardial function, and heart failure progression. The fundamental objective of modern medical therapy for heart failure is to reliev...
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ورودعنوان ژورنال:
- Hypertension
دوره 37 2 Pt 2 شماره
صفحات -
تاریخ انتشار 2001